WebbLiver fibrosis and cirrhosis are chronic liver diseases, resulting in life-threatening conditions with no FDA-approved therapy. Here, we identify bromodomain-containing … WebbLiver fibrosis is the result of a deregulated wound healing process characterized by the excessive deposition of extracellular matrix. Hepatic stellate cells (HSCs), which are …

Identifying collagen VI as a target of fibrotic diseases ... - PNAS

Webb12 apr. 2024 · Schematic depicting transforming growth factor (TGF)-β signaling in the context of the tumor microenvironment. TGFβ, a pleiotropic cytokine, controls cell growth, differentiation, inflammation, and angiogenesis in the tumor microenvironment. Cancer-associated fibroblasts and tumor cells produce latent TGFβ, which is deposited to the … WebbMyocardial regeneration in patients with cardiac damage is a long-sought goal of clinical medicine. In animal species in which regeneration occurs spontaneously, as well as in neonatal mammals, regeneration occurs through the proliferation of differentiated cardiomyocytes, which re-enter the cell cycle and proliferate. Hence, the reprogramming … deutsche bank travel card corona

Frontiers Novel Therapeutic Targets in Liver Fibrosis

WebbTEAD4 is essential for trophoblast progenitor self-renewal in early postimplantation mammalian embryos. Deficient TEAD4 expression has been implicated in early human pregnancy loss [ 7. ]. TEADs also have a role in the regeneration of organs such as liver, intestine, and heart and are also activated during wound healing [ 8. ]. Webb23 mars 2024 · The origins, subtypes and roles of cancer associated fibroblasts in HCC are discussed, including their specific roles in shaping the tumor microenvironment, facilitating cancer growth, and modulating different immune cell types to confer a permissive environment for cancer growth. Hepatocellular carcinoma (HCC) is the most common … WebbPurpose: The objective of this study was to identify the potential regulatory mechanisms, diagnostic biomarkers, and therapeutic drugs for heart failure (HF). Methods: Differentially expressed genes (DEGs) between HF and non-failing donors were screened from the GSE57345, GSE5406, and GSE3586 datasets. deutsche bank trainee solicitor