Cytokine secretion翻译
WebAbstract. Cytokines are small proteins secreted by cells of both innate and adaptive immune systems and can regulate diverse functions in the immune response. Dysregulation of cytokine secretion and their consequent signaling networks is an important component of the pathogenesis of autoimmune disease. In systemic lupus erythematosus (SLE), a ... WebIn summary, the analysis of rFlaA:Betv1-mediated cytokine secretion from ASC-, NLRP3-, or NLRC4-deficient THP-1 macrophages showed that our flagellin:antigen fusion protein could induce dual NLRP3- and NLRC4-inflammasome activation. Interestingly, both inflammasomes also contributed (either fully or only in part) to the secretion of other ...
Cytokine secretion翻译
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WebCytokine profile of human keratinocytes exposed to Malassezia globosa or Malassezia restricta.PHK16-0b cells (1 × 10 6 cells dish −1) were exposed to Malassezia globosa or Malassezia restricta at a multiplicity of infection of 20 for 24 h. Untreated cell cultures were used as the control. Cell culture supernatants were subject to a cytokine antibody array. WebJan 19, 2024 · Cytokine secretion has a tremendous impact on clinical diagnostics. Zhu et al. [34] reported Cytokine secretion detection at the single-cell level and real-time monitoring using localized surface ...
WebFeb 10, 2024 · In AS patients, proinflammatory cytokine may give positive feedback to induce more T-reg production and anti-inflammatory cytokine secretion to suppress this inflammatory status, and they can be reversed by anti-TNF-α therapy. However, the detailed interactions among T-regs and complex cytokine networks in autoinflammatory diseases … WebT cell responses are often diminished in humans with a compromised immune system. We have developed a method to isolate, stimulate and expand naïve cytotoxic T lymphocyte precurs
WebMar 18, 2010 · Studies have shown that cytokines, such as IL-2, IL-12, IL-15, and IL-21, can enhance IFN-γ and chemokine secretion induced by target cell recognition. 20,22,37-39 Therefore, we examined how exogenous cytokine stimulation by IL-12 plus IL-18 influenced NK-cell production of IFN-γ, TNF-α, MIP-1α, and MIP-1β upon interaction with …
WebSubject matter of the invention are antibody-cytokine fusion proteins having proapoptotic and immune modulating properties, but wherein the cytokine moiety a priori has a bioactivity which is very low or restricted to certain receptor subtypes. These reagent exert their full biological activity via the corresponding cytokine receptor(s) only after antibody …
Web细胞因子风暴(cytokine storm)是指机体感染微生物后引起体液中多种细胞因子如TNF-α、IL-1、IL-6、IL-12、IFN-α、IFN-β、IFN-γ、MCP-1和IL-8等迅速大量产生的现象，是引起急性呼吸窘迫综合症和多器官衰竭的重要原 … dvis best of brunchWebJan 10, 2014 · Thus, the cytokine secretion by a T cell population increases with foreign antigen concentrations, but is comprised of digital single-cell responses . Figure 1. Digital T cell response to antigen ... dvis careersWebTitanium (Ti) and copper (Cu) were used to evaluate cytokine secretion around materials with different chemical properties. Ti disks were coated with Cu or lef. 掌桥科研 一站式科研服务平台. 学术工具. 文档翻译; dvisd classlink launchpadWebCytokine secretion is a widely studied process, although little is known regarding the specific mechanisms that regulate cytokine release. Recent findings have shed light on … crystal bonin realtyWebJan 1, 2024 · Cytokines are critical mediators of communication for the immune system, and they are essential for host defense against pathogens. Cytokines can be secreted by immune cells but can also be produced by a wide variety of cells in response to infection, as with interferons, or can be produced or released from cells in response to cellular … crystal bongsWebThe cytokine secretion assay identifies live cytokine-secreting cells by capturing the secreted cytokine ona surface-bound capture antibody in dilutesuspension culture, fol-lowed by detection with a fluorescent anti-cytokine antibody. However, examining the kinetics of cytokine detection revealed that IL-2 staining reached a maximum at early dvisd athleticsWebDec 2, 2005 · Membrane traffic in activated macrophages is required for two critical events in innate immunity: proinflammatory cytokine secretion and phagocytosis of pathogens. We found a joint trafficking pathway linking both actions, which may economize membrane transport and augment the immune response. Tumor necrosis factor α (TNFα) is … crystal bonner lufkin